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EMD-48719

Single-particle
3.05 Å
EMD-48719
3D View Gallery
Deposition: 20/01/2025
Map released: 10/09/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48719
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9mxr summary report (pdf.gz) Map and 9mxr FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 Homodimer in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile (JLJ648), a Non-nucleoside Inhibitor

EMD-48719

Single-particle
3.05 Å
EMD-48719
3D View Gallery
Deposition: 20/01/2025
Map released: 10/09/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Human immunodeficiency virus 1
Sample: Human immunodeficiency virus 1
Fitted models: 9mxr

Deposition Authors: Hollander K , Devarkar SC, Tang S , Ma S, Xiong Y, Jorgensen WL, Anderson KS
Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Hollander K , Devarkar SC, Tang S , Tiwari R , Ma S, Lee WG, Denn E, Wang Q, Spasov KA, Robbins JA, Frey KM , Jorgensen WL, Xiong Y, Shan L, Anderson KS
(2025) Npj Drug Discov , 2 , 22 - 22
PUBMED: 40904837
DOI: doi:10.1038/s44386-025-00025-2
ISSN: 3005-1452