EMD-48717

Single-particle
2.1 Å
EMD-48717
3D View Gallery
Deposition: 20/01/2025
Map released: 06/08/2025
Last modified: 18/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48717

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mxl summary report (pdf.gz) Map-9mxl FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with (R)-BPO-27 and ATP/Mg

EMD-48717

Single-particle
2.1 Å
EMD-48717
3D View Gallery
Deposition: 20/01/2025
Map released: 06/08/2025
Last modified: 18/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of CFTR with the small molecule inhibitor (R)-BPO-27
Fitted models: 9mxl

Deposition Authors: Young PG , Fiedorczuk K, Chen J
Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism.
Young PG , Fiedorczuk K, Chen J
(2025) Nat Commun , 16 , 7059 - 7059
PUBMED: 40750590
DOI: doi:10.1038/s41467-025-62199-7
ISSN: 2041-1723