EMD-48339

Single-particle
3.68 Å
EMD-48339
3D View Gallery
Deposition: 18/12/2024
Map released: 11/02/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48339

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mkv summary report (pdf.gz) Map-9mkv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

FnoCas12a bridge helix variant state 3

EMD-48339

Single-particle
3.68 Å
EMD-48339
3D View Gallery
Deposition: 18/12/2024
Map released: 11/02/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Francisella tularensis subsp. novicida U112
Sample: Ternary complex of FnoCRISPR-Cas12a
Fitted models: 9mkv

Deposition Authors: Ganguly C , Thomas LM , Aribam SD , Martin L, Rajan R
Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation.
Ganguly C , Aribam SD , Dos Santos AM , Martin L, Thomas LM , Shao Y, Rajan R
(2026) Nat Commun , 17
PUBMED: 41605928
DOI: doi:10.1038/s41467-026-68657-0
ISSN: 2041-1723