EMD-48186
Antibody fragments from mAb21 and mAb824 bound to the adhesin protein FimH containing alpha-methyl mannose
EMD-48186
Single-particle3.1 Å
Deposition: 06/12/2024Map released: 26/11/2025
Last modified: 10/12/2025
Sample Organism:
Mus musculus,
Escherichia coli
Sample: Antibody fragments from mAb21 and mAb824 bound to the E. coli adhesin protein FimH containing alpha-methyl mannose
Fitted models: 9me7
Deposition Authors: Hvorecny KL
,
Magala P,
Klevit RE ,
Kollman JM
Sample: Antibody fragments from mAb21 and mAb824 bound to the E. coli adhesin protein FimH containing alpha-methyl mannose
Fitted models: 9me7
Deposition Authors: Hvorecny KL
,
Magala P,
Klevit RE ,
Kollman JM
Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference.
Hvorecny KL ,
Interlandi G,
Veth TS ,
Aprikian P,
Manchenko A ,
Tchesnokova VL,
Dickinson MS,
Quispe JD,
Riley NM ,
Klevit RE ,
Magala P,
Sokurenko EV,
Kollman JM
(2025) Nat Commun , 16 , 10590 - 10590
,
Interlandi G,
Veth TS ,
Aprikian P,
Manchenko A ,
Tchesnokova VL,
Dickinson MS,
Quispe JD,
Riley NM ,
Klevit RE ,
Magala P,
Sokurenko EV,
Kollman JM
(2025) Nat Commun , 16 , 10590 - 10590
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35 GM149542 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): F32 AI145111 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): 1R01 AI171570 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): K99 GM141364 (United States)