EMD-47792

Single-particle
3.24 Å
EMD-47792
3D View Gallery
Deposition: 08/11/2024
Map released: 11/02/2026
Last modified: 11/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47792

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9e9d summary report (pdf.gz) Map-9e9d FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of full length AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 in complex with anti-miR 17 oligonucleotide RGLS4326

EMD-47792

Single-particle
3.24 Å
EMD-47792
3D View Gallery
Deposition: 08/11/2024
Map released: 11/02/2026
Last modified: 11/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus
Sample: GluA2-y2 + oligo RGLS 4326
Fitted models: 9e9d

Deposition Authors: Yen LY, Gangwar SP , Yelshanskaya MV, Sobolevsky AI
The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.
Valencia T, Yen LY, Berman C, Vincent T, Davis S, Varrone F , Huang J, Mastroianni J, Carlson M, Owen T, Kamel A, Drygin D, Kinberger GA, Gangwar SP , Yelshanskaya MV, Ridley J, Kirby R, Alvarez J, Lakhia R , Patel V , Sobolevsky AI , Lee EC
(2025) Nat Commun , 16 , 10762 - 10762
PUBMED: 41315228
DOI: doi:10.1038/s41467-025-65799-5
ISSN: 2041-1723