EMD-47732

Helical reconstruction
3.0 Å
EMD-47732
3D View Gallery
Deposition: 06/11/2024
Map released: 12/11/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47732
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9e8v summary report (pdf.gz) Map and 9e8v FULL report (pdf.gz)
EMICSS annotations (xml)

Complex fibril structure of MSA alpha-synuclein with CNS-11g at 4 hours

EMD-47732

Helical reconstruction
3.0 Å
EMD-47732
3D View Gallery
Deposition: 06/11/2024
Map released: 12/11/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Alpha-synuclein with CNS-11g
Fitted models: 9e8v

Deposition Authors: Lu J, Sawaya MR, Ge P, Boyer DR, Eisenberg DS

The small molecule CNS-11g forms amyloid-like fibrils that disassemble pathological alpha-synuclein fibrils
Lu J, Sawaya MR, Cheng XY, Murrali MG, Ge P, Jiang YX, Cascio D, Lutter L, Boyer DR, Williams CK, Shino M, Feigon J, Chaturvedi S, Alexandrova A, Eisenberg DS
To Be Published