EMD-47698

Single-particle
3.3 Å
EMD-47698
3D View Gallery
Deposition: 04/11/2024
Map released: 03/12/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47698

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9e81 summary report (pdf.gz) Map-9e81 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of COP9 signalosome in complex with CSN5i-3

EMD-47698

Single-particle
3.3 Å
EMD-47698
3D View Gallery
Deposition: 04/11/2024
Map released: 03/12/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The complex of human COP9 signalosome with NEDD8 and CSN5i-3
Fitted models: 9e81

Deposition Authors: Shi H , Zheng N
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.
Shi H , Wang X, Yu C , Mao H, Jiao F, Braitbard M, Shor B, Zhang Z, Hinds TR, Cao S , Fan E, Schneidman-Duhovny D , Huang L , Zheng N
(2026) Nature , 652 , 1375 - 1383
PUBMED: 41673158
DOI: doi:10.1038/s41586-026-10129-y
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: