EMD-47665

Single-particle
3.7 Å
EMD-47665
3D View Gallery
Deposition: 01/11/2024
Map released: 03/12/2025
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47665
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Focused map of COP9 signalosome deneddylation state with cullin-5

EMD-47665

Single-particle
3.7 Å
EMD-47665
3D View Gallery
Deposition: 01/11/2024
Map released: 03/12/2025
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The complex of human COP9 signalosome with NEDD8 and CSN5i-3

Deposition Authors: Shi H , Zheng N
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.
Shi H , Wang X, Yu C , Mao H, Jiao F, Braitbard M, Shor B, Zhang Z, Hinds TR, Cao S , Fan E, Schneidman-Duhovny D , Huang L , Zheng N
(2026) Nature , 652 , 1375 - 1383
PUBMED: 41673158
DOI: doi:10.1038/s41586-026-10129-y
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: