EMD-47522

Single-particle
2.9 Å
EMD-47522
3D View Gallery
Deposition: 26/10/2024
Map released: 12/11/2025
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47522
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9e51 summary report (pdf.gz) Map and 9e51 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human LPHN2 (ADGRL2)/G13 complex in lipid nanodiscs

EMD-47522

Single-particle
2.9 Å
EMD-47522
3D View Gallery
Deposition: 26/10/2024
Map released: 12/11/2025
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: G13-bound human LPHN2 (ADGRL2) in lipid nanodiscs
Fitted models: 9e51

Deposition Authors: He F, Skiniotis G
The adhesion GPCR ADGRL2 engages G alpha 13 to enable epidermal differentiation.
Yang X , He F, Lopez-Pajares V , Porter DF , Garbett K , Siprashvili Z , Ducoli L, Meyers RM, Reynolds DL, Lan Huong Bui D, Hong A, Nguyen DT, Jing Y , Mondal S, Ko L , Tao S, Singal B, Sando R , Skiniotis G, Khavari PA
(2025) PNAS , 122 , e2508436122 - e2508436122
PUBMED: 41252157
DOI: doi:10.1073/pnas.2508436122
ISSN: 1091-6490
ASTM: PNASA6