EMD-47490

Single-particle
2.48 Å
EMD-47490
3D View Gallery
Deposition: 23/10/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47490
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9e3m summary report (pdf.gz) Map and 9e3m FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the human P2X7 receptor in the apo closed state

EMD-47490

Single-particle
2.48 Å
EMD-47490
3D View Gallery
Deposition: 23/10/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Membrane protein
Fitted models: 9e3m

Deposition Authors: Oken AC, Turcu AL, Vazquez S, Mansoor SE
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor.
Oken AC, Turcu AL, Tzortzini E, Georgiou K, Nagel J, Westermann FG, Barniol-Xicota M, Seidler J, Kim GR, Lee SD, Nicke A, Kim YC, Muller CE, Kolocouris A, Vazquez S, Mansoor SE
(2025) Nat Commun , 16 , 8283 - 8283
PUBMED: 40954149
DOI: doi:10.1038/s41467-025-62643-8
ISSN: 2041-1723