EMD-47298
Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Kukoamine-A
EMD-47298
Single-particle3.75 Å
Deposition: 11/10/2024Map released: 11/12/2024
Last modified: 11/12/2024
Sample Organism:
Rattus norvegicus
Sample: Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Kukoamine-A
Fitted models: 9dxt
Deposition Authors: Yen LY, Newton TP
,
Gangwar SP
,
Yelshanskaya MV,
Sobolevsky AI
Sample: Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Kukoamine-A
Fitted models: 9dxt
Deposition Authors: Yen LY, Newton TP
,
Gangwar SP
,
Yelshanskaya MV,
Sobolevsky AI
Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels.
Gangwar SP
,
Yelshanskaya MV,
Aktolun M,
Yen LY,
Newton TP
,
Stromgaard K
,
Kurnikova MG
,
Sobolevsky AI
(2024) Nat Commun , 15 , 10257 - 10257
,
Yelshanskaya MV,
Aktolun M,
Yen LY,
Newton TP
,
Stromgaard K
,
Kurnikova MG
,
Sobolevsky AI
(2024) Nat Commun , 15 , 10257 - 10257
Grant Support:
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS083660 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS107253 (United States)
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): R01 AR078814 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01 CA206573 (United States)
