EMD-47174
Cryo-EM Structure of CRBN:dHTC1:ENL YEATS
EMD-47174
Single-particle2.9 Å
Deposition: 04/10/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Homo sapiens
Sample: Ternary complex of dHTC1 induced DDB1dB/CRBN, ENL YEATS complex
Fitted models: 9dur
Deposition Authors: Cheong H
,
Hunkeler M ,
Fischer ES
Sample: Ternary complex of dHTC1 induced DDB1dB/CRBN, ENL YEATS complex
Fitted models: 9dur
Deposition Authors: Cheong H
,
Hunkeler M ,
Fischer ES
High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity.
Shaum JB ,
Munoz I Ordono M ,
Steen EA ,
Wenge DV ,
Cheong H ,
Hunkeler M ,
Bilotta EM ,
Rutter Z ,
Barta PA ,
Thornhill AM,
Milosevich N,
Hargis LM ,
Janowski J ,
Bishop TR ,
Carter TR ,
da Camara B ,
Hinterndorfer M ,
Dada L ,
He WJ ,
Offensperger F ,
Furihata H ,
Schweber SR,
Hatton C ,
Wen Y ,
Cravatt BF ,
Engle KM ,
Donovan KA ,
Melillo B ,
Kitamura S ,
Ciulli A ,
Armstrong SA ,
Fischer ES ,
Winter GE ,
Erb MA
(2025) bioRxiv
,
Munoz I Ordono M ,
Steen EA ,
Wenge DV ,
Cheong H ,
Hunkeler M ,
Bilotta EM ,
Rutter Z ,
Barta PA ,
Thornhill AM,
Milosevich N,
Hargis LM ,
Janowski J ,
Bishop TR ,
Carter TR ,
da Camara B ,
Hinterndorfer M ,
Dada L ,
He WJ ,
Offensperger F ,
Furihata H ,
Schweber SR,
Hatton C ,
Wen Y ,
Cravatt BF ,
Engle KM ,
Donovan KA ,
Melillo B ,
Kitamura S ,
Ciulli A ,
Armstrong SA ,
Fischer ES ,
Winter GE ,
Erb MA
(2025) bioRxiv
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