EMD-47025

Single-particle
3.35 Å
EMD-47025
3D View Gallery
Deposition: 16/09/2024
Map released: 18/06/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47025
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

Focused refinement map on C-terminal half of LRRK2 bound to RN277 (CORB-Kinase-WD40 domains)

EMD-47025

Single-particle
3.35 Å
EMD-47025
3D View Gallery
Deposition: 16/09/2024
Map released: 18/06/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: C-terminal half of LRRK2 bound to RN277

Deposition Authors: Sanz-Murillo M , Leschziner A
Type II kinase inhibitors that target Parkinson's disease-associated LRRK2.
Raig ND , Surridge KJ , Sanz-Murillo M , Dederer V , Kramer A , Schwalm MP , Lattal NM, Elson L , Chatterjee D, Mathea S , Hanke T , Leschziner AE , Reck-Peterson SL , Knapp S
(2025) Sci Adv , 11 , eadt2050 - eadt2050
PUBMED: 40465731
DOI: doi:10.1126/sciadv.adt2050
ISSN: 2375-2548
Grant Support: