EMD-46922

Single-particle
3.81 Å
EMD-46922
3D View Gallery
Deposition: 06/09/2024
Map released: 20/11/2024
Last modified: 04/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-46922

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

WEE1 bound to CRBN-DDB1 via compound 10 (CRBN closed conformation)

EMD-46922

Single-particle
3.81 Å
EMD-46922
3D View Gallery
Deposition: 06/09/2024
Map released: 20/11/2024
Last modified: 04/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of WEE1-compound10-CRBN/DDB1

Deposition Authors: Baek K , Fischer ES
Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.
Razumkov H, Jiang Z , Baek K , You I, Geng Q , Donovan KA , Tang MT , Metivier RJ, Mageed N, Seo P , Li Z , Byun WS , Hinshaw SM , Sarott RC , Fischer ES , Gray NS
(2024) J Am Chem Soc , 146 , 31433 - 31443
PUBMED: 39499896
DOI: doi:10.1021/jacs.4c06127
ISSN: 1520-5126
ASTM: JACSAT