EMD-46820

Single-particle
4.1 Å
EMD-46820
3D View Gallery
Deposition: 30/08/2024
Map released: 12/02/2025
Last modified: 09/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-46820

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dfx summary report (pdf.gz) Map-9dfx FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of a SUR1/Kir6.2 ATP-sensitive potassium channel in the presence of Aekatperone in the closed conformation

EMD-46820

Single-particle
4.1 Å
EMD-46820
3D View Gallery
Deposition: 30/08/2024
Map released: 12/02/2025
Last modified: 09/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus, Mesocricetus auratus
Sample: Kir6.2/SUR1 closed channel in complex with Aekatperone
Fitted models: 9dfx

Deposition Authors: Driggers CM , ElSheikh A , Shyng S-L
AI-based discovery and cryoEM structural elucidation of a K ATP channel pharmacochaperone.
Elsheikh A, Driggers CM , Truong HH, Yang Z, Allen J, Henriksen NM, Walczewska-Szewc K , Shyng SL
(2025) eLife , 13
PUBMED: 40135739
DOI: doi:10.7554/eLife.103159
ISSN: 2050-084X