EMDB EMD-4591

Single particle reconstruction
3.3Å resolution

Leishmania tarentolae proteasome 20S subunit apo structure

Map released:
Last modified:
Overview of EMD-4591
Source organism: Leishmania tarentolae [5689]
Fitted atomic model: 6qm8
Related EM entry by publication: EMD-4590
Primary publication:
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, Nuhs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG
Proc.Natl.Acad.Sci.USA 116 9318-9323 (2019)
PMID: 30962368

Function and Biology Details

Sample name: Proteasome 20S subunit
Proteins: Proteasome 20S subunit, Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, Proteasome alpha4 chain, Proteasome alpha5 chain, Proteasome alpha6 chain, Proteasome alpha7 chain, Proteasome beta1 chain, Proteasome beta2 chain, Proteasome beta3 chain, Proteasome beta4 chain, Proteasome beta5 chain, Proteasome beta6 chain, Proteasome beta7 chain

Experimental Information Details

Resolution: 3.3Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: FEI FALCON III (4k x 4k)