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EMD-45835
3A6 Fab fragment bound to Ebola GP, subtomogram average from a cylinder mask
EMD-45835
Subtomogram averaging17.7 Å
Deposition: 20/07/2024Map released: 18/12/2024
Last modified: 19/02/2025
Sample Organism:
Ebola virus - Eckron (Zaire, 1976)
Sample: Ebola virus - Eckron (Zaire, 1976)
Deposition Authors: Ke Z
,
Saphire EO ,
Briggs JAG
Sample: Ebola virus - Eckron (Zaire, 1976)
Deposition Authors: Ke Z
,
Saphire EO ,
Briggs JAG
Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP (1,2) in a position elevated from the virion membrane.
Hastie KM ,
Salie ZL ,
Ke Z ,
Halfmann PJ ,
DeWald LE,
McArdle S ,
Grinyo A ,
Davidson E,
Schendel SL ,
Hariharan C,
Norris MJ ,
Yu X ,
Chennareddy C,
Xiong X ,
Heinrich M ,
Holbrook MR ,
Doranz B ,
Crozier I ,
Kawaoka Y ,
Branco LM,
Kuhn JH ,
Briggs JAG ,
Worwa G,
Davis CW,
Ahmed R ,
Saphire EO
(2025) Nat Commun , 16 , 1293 - 1293
,
Salie ZL ,
Ke Z ,
Halfmann PJ ,
DeWald LE,
McArdle S ,
Grinyo A ,
Davidson E,
Schendel SL ,
Hariharan C,
Norris MJ ,
Yu X ,
Chennareddy C,
Xiong X ,
Heinrich M ,
Holbrook MR ,
Doranz B ,
Crozier I ,
Kawaoka Y ,
Branco LM,
Kuhn JH ,
Briggs JAG ,
Worwa G,
Davis CW,
Ahmed R ,
Saphire EO
(2025) Nat Commun , 16 , 1293 - 1293
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_1201/16 (United Kingdom)
- European Research Council (ERC): ERC-CoG-648432 MEMBRANEFUSION (European Union)
- Max Planck Society: (Germany)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U19 AI142790 (United States)