EMD-45226

Single-particle
3.36 Å
EMD-45226
3D View Gallery
Deposition: 06/06/2024
Map released: 01/10/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45226

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9c5v summary report (pdf.gz) Map-9c5v FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo EM structure of a DCAF2:degrader:BRD4 ternary complex

EMD-45226

Single-particle
3.36 Å
EMD-45226
3D View Gallery
Deposition: 06/06/2024
Map released: 01/10/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DCAF2:degrader:BRD4 ternary complex
Fitted models: 9c5v

Deposition Authors: McMahon EJ, Wang W
Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation.
McMahon EJ, Cioffi AG, Visperas PR, Lin Y, Shaghafi M, Daczkowski CM, Hermann JC, Everley RA, Neve RM, Erlanson DA, Webster KR, Narayan V, Wang W
(2025) Structure , 33 , 2020 - 2028.e7
PUBMED: 41045927
DOI: doi:10.1016/j.str.2025.09.006
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: