EMD-45186

Single-particle
5.8 Å
EMD-45186
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Deposition: 04/06/2024
Map released: 11/09/2024
Last modified: 11/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45186
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Cryo-EM structure of a FAM72A-MKLN1-RANBP9-TWA1 complex

EMD-45186

Single-particle
5.8 Å
EMD-45186
3D View Gallery
Deposition: 04/06/2024
Map released: 11/09/2024
Last modified: 11/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure a FAM72A-MKLN1-RANBP9-TWA1 subcomplex from focused refinement of CTLH-MKLN1-FAM72A in complex with UNG2

Deposition Authors: Chana CK, Keszei AFA, Sicheri F
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.
Barbulescu P, Chana CK, Wong MK, Ben Makhlouf I , Bruce JP, Feng Y , Keszei AFA, Wong C, Mohamad-Ramshan R, McGary LC, Kashem MA , Ceccarelli DF , Orlicky S, Fang Y, Kuang H, Mazhab-Jafari M, Pezo RC, Bhagwat AS , Pugh TJ , Gingras AC , Sicheri F , Martin A
(2024) Nat Commun , 15 , 7541 - 7541
PUBMED: 39215025
DOI: doi:10.1038/s41467-024-52009-x
ISSN: 2041-1723