EMD-44654

Single-particle
3.31 Å
EMD-44654
3D View Gallery
Deposition: 30/04/2024
Map released: 14/05/2025
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44654
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9blf summary report (pdf.gz) Map and 9blf FULL report (pdf.gz)
EMICSS annotations (xml)

SARS-CoV-2 core polymerase complex inhibited by araCTP

EMD-44654

Single-particle
3.31 Å
EMD-44654
3D View Gallery
Deposition: 30/04/2024
Map released: 14/05/2025
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, synthetic construct
Sample: SARS-CoV-2 nsp7, nsp8, nsp12 and an RNA primer-template bound to ara-CMP and ara-CTP
Fitted models: 9blf

Deposition Authors: Anderson TK , Kirchdeorfer RN
Incorporation of arabinose-CTP and arabinose-UTP inhibits viral polymerases by inducing long pauses.
Xiao Z , Das A, Jain A, Anderson TK , Cameron CE, Arnold JJ, Dulin D, Kirchdoerfer RN
(2026) J Biol Chem , 302 , 111027 - 111027
PUBMED: 41380964
DOI: doi:10.1016/j.jbc.2025.111027
ISSN: 1083-351X
ASTM: JBCHA3