EMD-44634

Single-particle
3.06 Å
EMD-44634
3D View Gallery
Deposition: 25/04/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44634

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9bjj summary report (pdf.gz) Map-9bjj FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of NVL bound the the MM017 inhibitor

EMD-44634

Single-particle
3.06 Å
EMD-44634
3D View Gallery
Deposition: 25/04/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: NVL bound to MM017 inhibitor
Fitted models: 9bjj

Deposition Authors: Cruz VE , Erzberger JP

Dibenzothiazepinones are bioavailable inhibitors of NVL and cause p53-dependent apoptosis in cancer by blocking 60S ribosome assembly
Guo HH , Tao Y , Cruz VE , Fang M, Khivansara V , Xie S, Leach A, Rivera-Cancel G , Barrows N , Williams N , Aurora A , Erzberger JP , De Brabander JK , Nijhawan D
To Be Published
Grant Support: