EMD-44633

Single-particle
2.83 Å
EMD-44633
3D View Gallery
Deposition: 25/04/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44633

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9bji summary report (pdf.gz) Map-9bji FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of apo NVL

EMD-44633

Single-particle
2.83 Å
EMD-44633
3D View Gallery
Deposition: 25/04/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Escherichia coli BL21(DE3)
Sample: apo NVL
Fitted models: 9bji

Deposition Authors: Cruz VE , Erzberger JP

Dibenzothiazepinones are bioavailable inhibitors of NVL and cause p53-dependent apoptosis in cancer by blocking 60S ribosome assembly
Guo HH, Tao Y , Cruz VE , Fang M, Khivansara V, Xie S, Leach A, Rivera-Cancel G , Barrows N, Williams N , Aurora A , Erzberger JP , De Brabander JK , Nijhawan D
To Be Published
Grant Support: