EMD-44386

Single-particle
2.6 Å
EMD-44386
3D View Gallery
Deposition: 02/04/2024
Map released: 05/02/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44386
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9b9j summary report (pdf.gz) Map and 9b9j FULL report (pdf.gz)
EMICSS annotations (xml)

Integrin alpha-5 beta-1 in complex with BIIG2 Fab

EMD-44386

Single-particle
2.6 Å
EMD-44386
3D View Gallery
Deposition: 02/04/2024
Map released: 05/02/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Rattus norvegicus
Sample: Protein complex of integrin alpha-5 beta-1 with BIIG2 Fab
Fitted models: 9b9j

Deposition Authors: Nguyen A , Azumaya CM , Campbell MG
Shared ligand-blocking mechanism but distinct conformational modulation by alpha 5-targeting antibodies BIIG2 and MINT1526A.
Nguyen A , Heim JB , Cordara G , Chan MC , Johannesen H , Charlesworth C, Li M, Azumaya CM , Madden B , Krengel U , Meves A , Campbell MG
(2025) bioRxiv
PUBMED: 39829743
DOI: doi:10.1101/2025.01.08.631572
ISSN: 2692-8205