EMD-44187

Helical reconstruction
3.5 Å
EMD-44187
3D View Gallery
Deposition: 21/03/2024
Map released: 12/03/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44187
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9b4o summary report (pdf.gz) Map and 9b4o FULL report (pdf.gz)
EMICSS annotations (xml)

Alzheimer's Tau Paired Helical Filaments, determined by CryoEM, before addition of D-peptide disaggregants

EMD-44187

Helical reconstruction
3.5 Å
EMD-44187
3D View Gallery
Deposition: 21/03/2024
Map released: 12/03/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Tau PHF
Fitted models: 9b4o

Deposition Authors: Hou K , Ge P , Sawaya MR , Eisenberg DS
How short peptides disassemble tau fibrils in Alzheimer's disease.
Hou K , Ge P , Sawaya MR , Lutter L, Dolinsky JL , Yang Y , Jiang YX , Boyer DR , Cheng X , Pi J , Zhang J, Lu J, Abskharon R, Yang S , Yu Z , Feigon J , Eisenberg DS
(2025) Nature , 644 , 1020 - 1027
PUBMED: 40634605
DOI: doi:10.1038/s41586-025-09244-z
ISSN: 1476-4687
ASTM: NATUAS