EMD-44186
Filament of Tau in complex with D-TLKIVWR, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM
EMD-44186
Helical reconstruction3.5 Å
Deposition: 21/03/2024Map released: 12/03/2025
Last modified: 03/09/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Tau PHF - D-TLKIVWR Complex
Fitted models: 9b4n
Deposition Authors: Hou K
,
Ge P ,
Sawaya MR ,
Eisenberg DS
Sample: Tau PHF - D-TLKIVWR Complex
Fitted models: 9b4n
Deposition Authors: Hou K
,
Ge P ,
Sawaya MR ,
Eisenberg DS
How short peptides disassemble tau fibrils in Alzheimer's disease.
Hou K ,
Ge P ,
Sawaya MR ,
Lutter L,
Dolinsky JL ,
Yang Y ,
Jiang YX ,
Boyer DR ,
Cheng X ,
Pi J ,
Zhang J,
Lu J,
Abskharon R,
Yang S ,
Yu Z ,
Feigon J ,
Eisenberg DS
(2025) Nature , 644 , 1020 - 1027
,
Ge P ,
Sawaya MR ,
Lutter L,
Dolinsky JL ,
Yang Y ,
Jiang YX ,
Boyer DR ,
Cheng X ,
Pi J ,
Zhang J,
Lu J,
Abskharon R,
Yang S ,
Yu Z ,
Feigon J ,
Eisenberg DS
(2025) Nature , 644 , 1020 - 1027
Grant Support:
- National Institutes of Health/National Institute on Aging (NIH/NIA): 1R01AG070895 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): RF1AG065407 (United States)
- Department of Energy (DOE, United States): DOE-FC02-02ERG (United States)