EMD-43678

Single-particle
4.07 Å
EMD-43678
3D View Gallery
Deposition: 09/02/2024
Map released: 28/05/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43678

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8vyu summary report (pdf.gz) Map-8vyu FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM Structure of the BRAF WT monomer bound to PLX8394

EMD-43678

Single-particle
4.07 Å
EMD-43678
3D View Gallery
Deposition: 09/02/2024
Map released: 28/05/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: BRAF WT - 14.3.3 complex bound to PLX8394
Fitted models: 8vyu

Deposition Authors: Lavoie H , Lajoie D , Jin T , Decossas M , Maisonneuve P , Therrien M
BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Lavoie H , Jin T , Lajoie D , Decossas M , Gendron P , Wang B , Filandr F , Sahmi M , Hwa Jo C, Weber S , Arseneault G , Tripathy S, Beaulieu P, Schuetz DA , Schriemer DC , Marinier A , Rice WJ , Maisonneuve P , Therrien M
(2025) Science , 388 , eadp2742 - eadp2742
PUBMED: 40440367
DOI: doi:10.1126/science.adp2742
ISSN: 1095-9203
ASTM: SCIEAS