EMD-43221

Single-particle
2.8 Å
EMD-43221
3D View Gallery
Deposition: 27/12/2023
Map released: 30/10/2024
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43221

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8vgq summary report (pdf.gz) Map-8vgq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of GNE-1952-alkylated KRAS G12C in complex with engineered conformationally rigid Fab 2H11.4DS

EMD-43221

Single-particle
2.8 Å
EMD-43221
3D View Gallery
Deposition: 27/12/2023
Map released: 30/10/2024
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: GNE-1952-alkylated KRAS G12C in complex with Fab 2H11.4DS
Fitted models: 8vgq

Deposition Authors: Kung JE , Sudhamsu J
Disulfi de constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM.
Kung JE , Johnson MC , Jao CC, Arthur CP, Tegunov D , Rohou A , Sudhamsu J
(2024) bioRxiv
PUBMED: 38798381
DOI: doi:10.1101/2024.05.10.593593
ISSN: 2692-8205
Grant Support: