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EMD-42636

Single-particle
2.88 Å
EMD-42636
3D View Gallery
Deposition: 05/11/2023
Map released: 11/09/2024
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-42636
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8uw1 summary report (pdf.gz) Map and 8uw1 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome

EMD-42636

Single-particle
2.88 Å
EMD-42636
3D View Gallery
Deposition: 05/11/2023
Map released: 11/09/2024
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Xenopus laevis, Escherichia coli 'BL21-Gold(DE3)pLysS AG', Homo sapiens
Sample: DNMT3A1 UDR in complex with H2AK119Ub-nucleosome
Fitted models: 8uw1

Deposition Authors: Gretarsson K , Abini-Agbomson S, Armache K-J, Lu C
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Gretarsson KH, Abini-Agbomson S, Gloor SL , Weinberg DN , McCuiston JL , Kumary VUS , Hickman AR , Sahu V, Lee R , Xu X, Lipieta N , Flashner S , Adeleke OA , Popova IK , Taylor HF, Noll K , Windham CL , Maryanski DN , Venters BJ , Nakagawa H , Keogh MC , Armache KJ , Lu C
(2024) Sci Adv , 10 , eadp0975 - eadp0975
PUBMED: 39196936
DOI: doi:10.1126/sciadv.adp0975
ISSN: 2375-2548