EMD-41729

Single-particle
3.43 Å
EMD-41729
3D View Gallery
Deposition: 26/08/2023
Map released: 04/12/2024
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41729
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8tyw summary report (pdf.gz) Map and 8tyw FULL report (pdf.gz)
EMICSS annotations (xml)

cryo-EM structure of GPR6-Gs-Nb35 complex

EMD-41729

Single-particle
3.43 Å
EMD-41729
3D View Gallery
Deposition: 26/08/2023
Map released: 04/12/2024
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: GPR6-Gs-Nb35 complex
Fitted models: 8tyw

Deposition Authors: Barekatain M , Johansson LC, Lam JH , Sadybekov AV , Han GW , Popov P, Russo J, Bliesath J, Brice N, Beresford M, Carlson L, Saikatendu KS , Sun H, Murphy S, Monenschein H, Schiffer HH, Lutomski C , Robinson CV , Liu J, Hua T , Katritch V , Cherezov V
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Barekatain M , Johansson LC, Lam JH , Chang H , Sadybekov AV , Han GW , Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS , Sun H, Murphy ST , Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV , Liu ZJ , Hua T , Katritch V , Cherezov V
(2024) Sci Signal , 17 , eado8741 - eado8741
PUBMED: 39626010
DOI: doi:10.1126/scisignal.ado8741
ISSN: 1937-9145