EMDB EMD-4160

Single particle reconstruction
3.2Å resolution

Imidazoleglycerol-phosphate dehydratase from Saccharomyces cerevisiae

Map released:
Last modified:
Overview of EMD-4160
Fitted atomic model: 6ezm
Related EM entry by publication: EMD-3999
Primary publication:
Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Rawson S, Bisson C, Hurdiss DL, Fazal A, McPhillie MJ, Sedelnikova SE, Baker PJ, Rice DW, Muench SP
Proc. Natl. Acad. Sci. U.S.A. 115 1795-1800 (2018)
PMID: 29434040

Function and Biology Details

Sample name: Imidazoleglycerol-phosphate dehydratase (IGPD) in complex with triazole-phosphonate inhibitor (C384)
Ligands: MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid
Proteins: Imidazoleglycerol-phosphate dehydratase (IGPD) in complex with triazole-phosphonate inhibitor (C384), Imidazoleglycerol-phosphate dehydratase

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: O
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER