EMD-41145

Single-particle
2.94 Å
EMD-41145
3D View Gallery
Deposition: 28/06/2023
Map released: 04/10/2023
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41145

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8tb7 summary report (pdf.gz) Map-8tb7 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM Structure of GPR61-

EMD-41145

Single-particle
2.94 Å
EMD-41145
3D View Gallery
Deposition: 28/06/2023
Map released: 04/10/2023
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: GPR61-ICL3-BRIL chimera in complex with anti-BRIL Fab24 BAK5 and hinge-binding nanobody bound to inverse agonist Compound 1
Fitted models: 8tb7

Deposition Authors: Lees JA , Dias JM , Han S
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Lees JA , Dias JM , Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG , Fisher EL , Tuttle JB, Lovett G, Kormos BL , Unwalla RJ, Zhang L, Dechert Schmitt AM, Zhou D, Moran M , Stevens KA, Fennell KF, Varghese AE, Maxwell A, Cote EE, Zhang Y, Han S
(2023) Nat Commun , 14 , 5938 - 5938
PUBMED: 37741852
DOI: doi:10.1038/s41467-023-41646-3
ISSN: 2041-1723
Grant Support: