EMD-40881

Single-particle
3.71 Å
EMD-40881
3D View Gallery
Deposition: 25/05/2023
Map released: 29/05/2024
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40881
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Raw consensus map of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state

EMD-40881

Single-particle
3.71 Å
EMD-40881
3D View Gallery
Deposition: 25/05/2023
Map released: 29/05/2024
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Salpingoeca rosetta
Sample: TRPM2 chanzyme incubated with Magnesium and ADP-ribose for 10s; ADP-ribose partially hydrolyzed; intact ADP-ribose in MHR1/2 domain; Adenosine monophosphate and Ribose-5-phosphate in NUDT9-H domain; closed state.

Deposition Authors: Huang Y , Kumar S , Lu W , Du J
Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Huang Y , Kumar S , Lee J , Lu W , Du J
(2024) Nat Struct Mol Biol , 31 , 1509 - 1521
PUBMED: 38773335
DOI: doi:10.1038/s41594-024-01316-4
ISSN: 1545-9985