EMD-40825
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
EMD-40825
Single-particle4.0 Å
Deposition: 19/05/2023Map released: 22/05/2024
Last modified: 04/06/2025
Sample Organism:
Mus musculus,
Homo sapiens,
synthetic construct
Sample: 10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Fitted models: 8sx3
Deposition Authors: Huang J, Ozorowski G
,
Ward AB
Sample: 10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Fitted models: 8sx3
Deposition Authors: Huang J, Ozorowski G
,
Ward AB
Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Schiffner T ,
Phung I ,
Ray R,
Irimia A,
Tian M,
Swanson O ,
Lee JH,
Lee CD ,
Marina-Zarate E ,
Cho SY,
Huang J,
Ozorowski G ,
Skog PD,
Serra AM,
Rantalainen K ,
Allen JD ,
Baboo S ,
Rodriguez OL ,
Himansu S ,
Zhou J,
Hurtado J,
Flynn CT,
McKenney K,
Havenar-Daughton C,
Saha S ,
Shields K,
Schulze S,
Smith ML,
Liang CH,
Toy L,
Pecetta S ,
Lin YC ,
Willis JR ,
Sesterhenn F,
Kulp DW ,
Hu X,
Cottrell CA ,
Zhou X,
Ruiz J,
Wang X,
Nair U,
Kirsch KH,
Cheng HL,
Davis J ,
Kalyuzhniy O ,
Liguori A,
Diedrich JK,
Ngo JT,
Lewis V,
Phelps N,
Tingle RD,
Spencer S ,
Georgeson E ,
Adachi Y,
Kubitz M,
Eskandarzadeh S,
Elsliger MA,
Amara RR ,
Landais E ,
Briney B,
Burton DR ,
Carnathan DG,
Silvestri G ,
Watson CT ,
Yates 3rd JR ,
Paulson JC ,
Crispin M ,
Grigoryan G,
Ward AB ,
Sok D ,
Alt FW,
Wilson IA ,
Batista FD ,
Crotty S ,
Schief WR
(2024) Nat Immunol , 25 , 1073 - 1082
,
Phung I ,
Ray R,
Irimia A,
Tian M,
Swanson O ,
Lee JH,
Lee CD ,
Marina-Zarate E ,
Cho SY,
Huang J,
Ozorowski G ,
Skog PD,
Serra AM,
Rantalainen K ,
Allen JD ,
Baboo S ,
Rodriguez OL ,
Himansu S ,
Zhou J,
Hurtado J,
Flynn CT,
McKenney K,
Havenar-Daughton C,
Saha S ,
Shields K,
Schulze S,
Smith ML,
Liang CH,
Toy L,
Pecetta S ,
Lin YC ,
Willis JR ,
Sesterhenn F,
Kulp DW ,
Hu X,
Cottrell CA ,
Zhou X,
Ruiz J,
Wang X,
Nair U,
Kirsch KH,
Cheng HL,
Davis J ,
Kalyuzhniy O ,
Liguori A,
Diedrich JK,
Ngo JT,
Lewis V,
Phelps N,
Tingle RD,
Spencer S ,
Georgeson E ,
Adachi Y,
Kubitz M,
Eskandarzadeh S,
Elsliger MA,
Amara RR ,
Landais E ,
Briney B,
Burton DR ,
Carnathan DG,
Silvestri G ,
Watson CT ,
Yates 3rd JR ,
Paulson JC ,
Crispin M ,
Grigoryan G,
Ward AB ,
Sok D ,
Alt FW,
Wilson IA ,
Batista FD ,
Crotty S ,
Schief WR
(2024) Nat Immunol , 25 , 1073 - 1082
Grant Support:
- Bill & Melinda Gates Foundation: INV-002916 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): UM1 AI144462 (United States)