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EMD-40745

Single-particle
3.01 Å
EMD-40745
3D View Gallery
Deposition: 08/05/2023
Map released: 06/09/2023
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40745
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8ss6 summary report (pdf.gz) Map and 8ss6 FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)

EMD-40745

Single-particle
3.01 Å
EMD-40745
3D View Gallery
Deposition: 08/05/2023
Map released: 06/09/2023
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus, Homo sapiens
Sample: GluA2-TARP gamma5-cornichon-2
Fitted models: 8ss6

Deposition Authors: Gangwar SP , Yen LY, Yelshanskaya MV, Sobolevsky AI
Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Gangwar SP , Yen LY, Yelshanskaya MV, Korman A , Jones DR , Sobolevsky AI
(2023) Nat Struct Mol Biol , 30 , 1481 - 1494
PUBMED: 37653241
DOI: doi:10.1038/s41594-023-01080-x
ISSN: 1545-9985