EMD-40603
GPR161 Gs heterotrimer
EMD-40603
Single-particle2.74 Å
Deposition: 26/04/2023Map released: 21/02/2024
Last modified: 16/10/2024
Sample Organism:
Homo sapiens,
Lama glama
Sample: GPR161 Gs heterotrimeric complex with Nb35
Fitted models: 8smv
Deposition Authors: Hoppe N, Manglik A
,
Harrison S
Sample: GPR161 Gs heterotrimeric complex with Nb35
Fitted models: 8smv
Deposition Authors: Hoppe N, Manglik A
,
Harrison S
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N,
Harrison S,
Hwang SH,
Chen Z,
Karelina M ,
Deshpande I,
Suomivuori CM ,
Palicharla VR,
Berry SP ,
Tschaikner P,
Regele D,
Covey DF ,
Stefan E ,
Marks DS ,
Reiter JF,
Dror RO ,
Evers AS ,
Mukhopadhyay S ,
Manglik A
(2024) Nat Struct Mol Biol , 31 , 667 - 677
,
Deshpande I,
Suomivuori CM ,
Palicharla VR,
Berry SP ,
Tschaikner P,
Regele D,
Covey DF ,
Stefan E ,
Marks DS ,
Reiter JF,
Dror RO ,
Evers AS ,
Mukhopadhyay S ,
Manglik A
(2024) Nat Struct Mol Biol , 31 , 667 - 677
Secondary citations:
- Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S & Manglik A. (2023) GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. bioRxiv,
- Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S & Manglik A. (2024) GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nat Struct Mol Biol,
Grant Support: