EMD-39843

Single-particle
2.82 Å
EMD-39843
3D View Gallery
Deposition: 21/04/2024
Map released: 29/10/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-39843

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8z8a summary report (pdf.gz) Map-8z8a FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the Lactate-bound human HCAR1-Gi1 complex

EMD-39843

Single-particle
2.82 Å
EMD-39843
3D View Gallery
Deposition: 21/04/2024
Map released: 29/10/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM structure of the Lactate-bound human HCAR1-Gi1 complex
Fitted models: 8z8a

Deposition Authors: Gao M , Zang S, Zhu Y , Mao C , Zhang Y , Ma X
Structural insights into the activation mechanism of the human metabolite receptor HCAR1.
Gao M , Zang S, Zhu Y , Xi K , Du Y, Cheng S, Miao L , Lu Y , Mao C , Zhang Y , Ma X
(2026) Sci Signal , 19 , eadw1483 - eadw1483
PUBMED: 41493973
DOI: doi:10.1126/scisignal.adw1483
ISSN: 1937-9145
Grant Support: