EMD-39622

Single-particle
3.26 Å
EMD-39622
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Deposition: 29/03/2024
Map released: 18/09/2024
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-39622
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8yw4 summary report (pdf.gz) Map and 8yw4 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex

EMD-39622

Single-particle
3.26 Å
EMD-39622
3D View Gallery
Deposition: 29/03/2024
Map released: 18/09/2024
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Fitted models: 8yw4

Deposition Authors: Li WZ, Zhou QT, Cong ZT, Yuan QN, Li WX, Zhao FH, Xu HE , Zhao LH, Yang DH, Wang MW
Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Li W, Zhou Q , Cong Z, Yuan Q, Li W, Zhao F, Xu HE , Zhao LH, Yang D , Wang MW
(2024) Cell Discov , 10 , 77 - 77
PUBMED: 39019866
DOI: doi:10.1038/s41421-024-00700-0
ISSN: 2056-5968