EMD-38357

Single-particle
3.1 Å
EMD-38357
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Deposition: 18/12/2023
Map released: 06/11/2024
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-38357
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Human Cx36/GJD2 (Ala14 deletion mutant) gap junction channel prepared with mefloquine, showing no bound mefloquine (C1 symmetry)

EMD-38357

Single-particle
3.1 Å
EMD-38357
3D View Gallery
Deposition: 18/12/2023
Map released: 06/11/2024
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human Cx36/GJD2 (Ala14 deletion mutant) gap junction channel in brain lipids

Deposition Authors: Cho HJ , Lee HH
Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer.
Cho HJ , Chung DK, Lee HH
(2024) Nat Commun , 15 , 9223 - 9223
PUBMED: 39455592
DOI: doi:10.1038/s41467-024-53587-6
ISSN: 2041-1723
Grant Support: