EMD-36948

Single-particle
2.6 Å
EMD-36948
3D View Gallery
Deposition: 29/07/2023
Map released: 31/01/2024
Last modified: 16/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-36948

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8k8e summary report (pdf.gz) Map-8k8e FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human gamma-secretase in complex with a substrate mimetic

EMD-36948

Single-particle
2.6 Å
EMD-36948
3D View Gallery
Deposition: 29/07/2023
Map released: 31/01/2024
Last modified: 16/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Human gamma-secretase
Fitted models: 8k8e

Deposition Authors: Shi YG, Zhou R, Wolfe MS
Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes.
Devkota S, Zhou R, Nagarajan V, Maesako M, Do H, Noorani A, Overmeyer C, Bhattarai S, Douglas JT, Saraf A, Miao Y, Ackley BD , Shi Y, Wolfe MS
(2024) Cell Rep , 43 , 113761 - 113761
PUBMED: 38349793
DOI: doi:10.1016/j.celrep.2024.113761
ISSN: 2211-1247