EMD-36593

Single-particle
2.57 Å
EMD-36593
3D View Gallery
Deposition: 16/06/2023
Map released: 02/08/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-36593
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8jr9 summary report (pdf.gz) Map and 8jr9 FULL report (pdf.gz)
EMICSS annotations (xml)

Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)

EMD-36593

Single-particle
2.57 Å
EMD-36593
3D View Gallery
Deposition: 16/06/2023
Map released: 02/08/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: A conserved and druggable pocket in class B G protein coupled receptors for 2 orally active small molecule agonists
Fitted models: 8jr9

Deposition Authors: Zhao L , He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE
Conserved class B GPCR activation by a biased intracellular agonist.
Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE
(2023) Nature , 621 , 635 - 641
PUBMED: 37524305
DOI: doi:10.1038/s41586-023-06467-w
ISSN: 1476-4687
ASTM: NATUAS