EMD-35526
Cryo-EM structure of CD38 in complex with FTL004
EMD-35526
Single-particle3.86 Å
Deposition: 01/03/2023Map released: 29/03/2023
Last modified: 18/06/2025
Sample Organism:
Homo sapiens
Sample: Cryo-EM structure of CD38 in complex with FTL004
Fitted models: 8il3
Deposition Authors: Yang J, Wang Y, Zhang G
Sample: Cryo-EM structure of CD38 in complex with FTL004
Fitted models: 8il3
Deposition Authors: Yang J, Wang Y, Zhang G
FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma.
Zhang G,
Guo C,
Wang Y,
Zhang X,
Liu S,
Qu W,
Chen C,
Yan L,
Yang Z,
Zhang Z,
Jiang X,
Chen X,
Liu H,
Lai Q,
Wei X,
Lu Y,
Zhao S,
Deng H,
Wang Y,
Yu L,
Yu H,
Wu Y,
Su Z 
,
Chen P,
Ren Z,
Yu M,
Qu F,
Luo Y,
Gou L,
Li Q,
Huang Y,
Ma F,
Yang J
(2022) J Hematol Oncol , 15 , 177 - 177
,
Chen P,
Ren Z,
Yu M,
Qu F,
Luo Y,
Gou L,
Li Q,
Huang Y,
Ma F,
Yang J
(2022) J Hematol Oncol , 15 , 177 - 177
Grant Support:
- National Natural Science Foundation of China (NSFC): 32070049 (China)
- National Natural Science Foundation of China (NSFC): 32222040 (China)
- National Natural Science Foundation of China (NSFC): 81872907 (China)
- Other government: 2020YFSY0025
- Other government: 2021YJ0454
- Other government: 2019YFS0003
- Ministry of Science and Technology (MoST, China): 2021YFA1301900 (China)
- Other government: 20822041D4057
- CAMS Innovation Fund for Medical Sciences (CIFMS): 2021-I2M-5-075 (United Kingdom)
- Other government: 2018ZX09201018-021
- Other government: 2017ZX09302010