EMDB EMD-3523

Single particle reconstruction
4.3Å resolution

cryoEM Structure of Polycystin-2 in complex with cations and lipids

Map released:
Last modified:
Overview of EMD-3523
Source organism: Homo sapiens [9606]
Fitted atomic model: 5mke
Related EM entry by publication: EMD-3524
Primary publication:
Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kuhlbrandt W, Witzgall R, Ziegler C
Nat. Struct. Mol. Biol. 24 123-130 (2017)
PMID: 28092368

Function and Biology Details

Sample name: Polycystin-2
Ligands: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINO-5-CYCLOHEXYL-3-HYDROXY-PENTANOIC ACID, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, PALMITIC ACID, CALCIUM ION
Proteins: Polycystin-2, Polycystin-2

Experimental Information Details

Resolution: 4.3Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Microscope: JEOL 3200FSC
Detector: GATAN K2 SUMMIT (4k x 4k)