EMD-33127

Single-particle
2.72 Å
EMD-33127
3D View Gallery
Deposition: 25/03/2022
Map released: 20/04/2022
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-33127
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7xct summary report (pdf.gz) Map and 7xct FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex

EMD-33127

Single-particle
2.72 Å
EMD-33127
3D View Gallery
Deposition: 25/03/2022
Map released: 20/04/2022
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Complex of Dot1L(1-416) and H2BK34ub 2:1 nucleosome
Fitted models: 7xct

Deposition Authors: Ai HS, Liu AJ, Lou ZY, Liu L
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Ai H , Sun M , Liu A, Sun Z, Liu T, Cao L, Liang L , Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H , Zhao S , Li JB , Lou Z , Liu L
(2022) Nat Chem Biol , 18 , 972 - 980
PUBMED: 35739357
DOI: doi:10.1038/s41589-022-01067-7
ISSN: 1552-4469