Electron Microscopy Data Bank

EMD-32488

Single-particle
3.4 Å

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Deposition: 28/12/2021
Map released: 02/02/2022
Last modified: 24/08/2022

Overview 3D View Sample Experiment Validation Additional data Links

EMD-32488

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TM domain of human Kv1.3 channel in dalazatide-bound state

EMD-32488

Single-particle
3.4 Å
EMD-32488

3D View Gallery

Deposition: 28/12/2021
Map released: 02/02/2022
Last modified: 24/08/2022

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Homo sapiens
Sample: TM domain of human Kv1.3 channel in dalazatide-bound state

Deposition Authors: Tyagi A , Ahmed T, Jian S, Bajaj S , Ong ST , Goay SSM , Zhao Y, Vorobyov I , Tian C, Chandy KG , Bhushan S

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.

Tyagi A , Ahmed T, Jian S, Bajaj S , Ong ST , Goay SSM , Zhao Y, Vorobyov I , Tian C, Chandy KG , Bhushan S
(2022) PNAS , 119

PUBMED: 35091471
DOI: doi:10.1073/pnas.2113536119
ISSN: 1091-6490
ASTM: PNASA6

Grant Support:

Ministry of Education (MoE, Singapore): MOE2017-T2-2-089, MOE2020-T1-002-059, MOE2016-T2-2-032 (Singapore)