EMDB EMD-3237

Single particle reconstruction
4.2Å resolution

Cryo-EM structure of gamma secretase in complex with a drug DAPT

Map released:
Last modified:
Overview of EMD-3237
Source organism: Homo sapiens [9606]
Fitted atomic model: 5fn2
Related EM entries by publication: EMD-3238, EMD-3239, EMD-3240
Primary publication:
Sampling the conformational space of the catalytic subunit of human gamma-secretase
Bai XC, Rajendra E, Yang GH, Shi YG, Scheres SHW
Elife 4 (2015)
PMID: 26623517

Function and Biology Details

Sample name: human gamma secretase in complex with a drug DAPT
Protein: gamma-secretase

Experimental Information Details

Resolution: 4.2Å
Resolution method: FSC 0.143, gold-standard
Applied symmetry: C1
Reconstruction software: CTFFIND4, RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)