EMD-32342

Single-particle
3.4 Å
EMD-32342
3D View Gallery
Deposition: 04/12/2021
Map released: 28/09/2022
Last modified: 09/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-32342

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7w7e summary report (pdf.gz) Map-7w7e FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist

EMD-32342

Single-particle
3.4 Å
EMD-32342
3D View Gallery
Deposition: 04/12/2021
Map released: 28/09/2022
Last modified: 09/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Signaling complex of alpha2A adrenergic receptor with GoA
Fitted models: 7w7e

Deposition Authors: Xu J , Fink EA
Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor.
Fink EA , Xu J , Hubner H, Braz JM , Seemann P , Avet C, Craik V , Weikert D , Schmidt MF , Webb CM, Tolmachova NA, Moroz YS , Huang XP , Kalyanaraman C , Gahbauer S , Chen G, Liu Z , Jacobson MP , Irwin JJ , Bouvier M , Du Y , Shoichet BK , Basbaum AI , Gmeiner P
(2022) Science , 377 , eabn7065 - eabn7065
PUBMED: 36173843
DOI: doi:10.1126/science.abn7065
ISSN: 1095-9203
ASTM: SCIEAS