EMD-31879

Single-particle
3.0 Å
EMD-31879
3D View Gallery
Deposition: 31/08/2021
Map released: 06/04/2022
Last modified: 06/04/2022
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-31879
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7vbh summary report (pdf.gz) Map and 7vbh FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex

EMD-31879

Single-particle
3.0 Å
EMD-31879
3D View Gallery
Deposition: 31/08/2021
Map released: 06/04/2022
Last modified: 06/04/2022
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Escherichia coli, Rattus norvegicus, Bos taurus
Sample: Cryo-EM structure of the human glucagon-like peptide-1 receptor in complex with Peptide 20 and G protein
Fitted models: 7vbh

Deposition Authors: Zhao FH, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y , Wu BL, Yang DH, Zhao LH, Xu HE , Wang MW
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P , Chang R, Feng W, Xia T, Zhang Y , Wu B , Yang D , Zhao L , Xu HE , Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
PUBMED: 35217653
DOI: doi:10.1038/s41467-022-28683-0
ISSN: 2041-1723