EMD-31536
Thermostabilised full length human mGluR5-5M bound with L-quisqualic acid
EMD-31536
Single-particle3.8 Å
Deposition: 16/07/2021Map released: 08/09/2021
Last modified: 30/10/2024
Sample Organism:
Homo sapiens
Sample: Human FL mGluR5-5M with L-quisqualic acid and PAM VU0424465, agonist bound state
Fitted models: 7fd8
Deposition Authors: Vinothkumar KR, Cannone G
Sample: Human FL mGluR5-5M with L-quisqualic acid and PAM VU0424465, agonist bound state
Fitted models: 7fd8
Deposition Authors: Vinothkumar KR, Cannone G
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Nasrallah C,
Cannone G,
Briot J 
,
Rottier K,
Berizzi AE,
Huang CY,
Quast RB ,
Hoh F ,
Baneres JL ,
Malhaire F ,
Berto L,
Dumazer A ,
Font-Ingles J,
Gomez-Santacana X ,
Catena J,
Kniazeff J,
Goudet C ,
Llebaria A,
Pin JP,
Vinothkumar KR,
Lebon G
(2021) Cell Rep , 36 , 109648 - 109648
,
Rottier K,
Berizzi AE,
Huang CY,
Quast RB ,
Hoh F ,
Baneres JL ,
Malhaire F ,
Berto L,
Dumazer A ,
Font-Ingles J,
Gomez-Santacana X ,
Catena J,
Kniazeff J,
Goudet C ,
Llebaria A,
Pin JP,
Vinothkumar KR,
Lebon G
(2021) Cell Rep , 36 , 109648 - 109648
Grant Support:
- Department of Biotechnology (DBT, India): DBT/PR12422/MED/31/287/2014 (India)
- Science and Engineering Research Board (SERB): RJN-094/2017 (India)
- Medical Research Council (MRC, United Kingdom): MC-U105184322 (United Kingdom)
- Agence Nationale de la Recherche (ANR): ANR-17-CE18-0001 (France)
- Agence Nationale de la Recherche (ANR): ANR-18-CE11-0001 (France)