EMDB EMD-30505

Single particle reconstruction
2.6Å resolution

Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex

Map released:
Overview of EMD-30505
Source organisms:
Fitted atomic model: 7cz5
Primary publication:
Structural basis for activation of the growth hormone-releasing hormone receptor.
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun 11 5205-5205 (2020)
PMID: 33060564

Function and Biology Details

Sample name: Growth hormone-releasing hormone receptor - Gs protein complex
Ligands: PALMITIC ACID, CHOLESTEROL, water
Proteins: Growth hormone-releasing hormone receptor - Gs protein complex, hormone receptor, G(s) subunit alpha isoforms, hormone, G(s) subunit beta-1, G(s) subunit gamma-2, Nanobody35, Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Somatoliberin, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody35

Experimental Information Details

Resolution: 2.6Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)