EMDB EMD-30448

Single particle reconstruction
3.7Å resolution

human KCNQ2-CaM in complex with retigabine

Map released:
Overview of EMD-30448
Source organism: Human [9606]
Fitted atomic model: 7cr7
Related EM entries by publication: EMD-30443, EMD-30444, EMD-30445, EMD-30446, EMD-30447
Primary publication:
Molecular basis for ligand activation of the human KCNQ2 channel.
Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J
Cell Res. - (2020)
PMID: 32884139

Function and Biology Details

Sample name: voltage-gated potassium channel KCNQ2
Ligand: ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
Proteins: voltage-gated potassium channel KCNQ2, Potassium voltage-gated channel subfamily KQT member 2, Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2, Calmodulin-3

Experimental Information Details

Resolution: 3.7Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)